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 Product Name: SB203580
 CAS No.: 152121-47-6
 Molecular Structural SB203580
 Molecular Formula:
 Molecular Weight:
 Other:  Prouduct Name:SB203580

Chemical Name:4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]pyridine

M.Wt: 377.43

Formula: C21H16FN3OS

appearance:yellow powder

Solubility: Soluble to 25 mM in DMSO and to 100 mM in 1eq. HCl


Storage: Desiccate at +4°C

CAS No: 152121-47-6

SB203580 inhibits the IL-2-induced proliferation of primary human T cells, murine CT6 T cells, or BAF F7 B cells with an IC50 of 3–5 μm. SB203580 also inhibits IL-2-induced p70S6 kinase activation, although the concentration required is slightly higher with an IC50 above 10 μm. SB203580 also inhibits the activity of PDK1 in a dose-dependent manner with an IC50 in the 3–10 μm range. SB203580 inhibits p38-MAPK stimulation of MAPKAPK2 with an IC50 of approximately 0.07 μM, whereas inhibits total SAPK/JNK activity with an IC50 of 3–10 μM. SB203580 at higher concentrations activates the ERK pathway, which subsequently enhances NF-κB transcriptional activity. SB203580 induces autophagy in human hepatocellular carcinoma (HCC) cells.

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